v. 1
To hinder or thwart.
My clumsy fingers frustrate my typing efforts.
v. 2
To cause stress or annoyance.
This test frustrates me because if I fail, it'll destroy my grade.
v. 3
To disappoint or defeat; to vex by depriving of something expected or desired.
It frustrates me to do all this work and then lose it all.

Related words

Forms

Past participle: frustrated
e.g. frustrated → thwarted, hindered, prevented, disappointed…

prevent Eating healthfully can help prevent heart disease.
disappoint Don't disappoint me the way you did the other day.
hinder If you cannot help us, don't at least hinder us.
thwart A moat was dug around the castle to thwart attackers.
exasperate Sorry, I didn't mean to exasperate you with my endless questions.

Use in printed books, per decade from 1850 to 2019.

3 letters: rag¹, dun¹, vex¹
4 letters: dash¹, foil¹, undo², balk¹, rile¹, bilk¹
5 letters: cross¹, blast¹, spoil¹, queer¹, annoy², elude², baulk
6 letters: defeat², scotch¹, hinder², retard², hamper², thwart¹, impede², molest², baffle², stymie²
7 letters: prevent², provoke², torment², inhibit³, nullify³, crucify³, bedevil³
8 letters: prohibit³, obstruct², irritate³, preclude², confound²
9 letters: interfere³, undermine³, aggravate³, persecute³, tantalize³, tantalise
10 letters: disappoint³, counteract³, circumvent³, exasperate⁴, disconcert³

The small number after each word is its number of syllables (undo² = 2 syllables).