v. 1
To annoy, to disturb, to irritate; to be troublesome to, to make trouble for.
Would it bother you if I smoked?
v. 2
To feel care or concern; to burden or inconvenience oneself out of concern.
I never bother about such trivialities.
n. 1
Fuss, ado.
There was a bit of bother at the hairdresser's when they couldn't find my appointment in the book.
interj. 1
A mild expression of annoyance.

Forms

Plural: bothers → troubles, fusses, stirs, to-dos…
Past participle: bothered
e.g. bothered → annoyed, vexed, disturbed, pestered…

Example sentences

Use in printed books, per decade from 1850 to 2019.

3 letters: get¹, eat¹, ado², vex¹, irk¹
4 letters: care¹, mind¹, pain¹, riot², stir¹, bore¹, fuss¹, darn¹, dang¹, flap¹, gnaw¹, rile¹, drat
5 letters: worry², upset², devil², chaos², blast¹, tease¹, annoy²
6 letters: plague¹, hassle², harass², uproar², bustle², ruckus², molest², pester², pucker², fracas², rumpus
7 letters: trouble², disturb², flutter², ferment², palaver, perturb², perplex²
8 letters: headache², nuisance², irritate³, irritant³, brouhaha³, vexation
9 letters: confusion³, annoyance³, commotion³, grievance²
10 letters: irritation⁴, hullabaloo⁴, perplexity⁴
11 letters: disturbance³, botheration
13 letters: inconvenience⁴

The small number after each word is its number of syllables (ado² = 2 syllables).